Böhm M, Blasius S, Roessner A
Institue für Pathologie, Otto-von-Guericke-Universität Magdeburg, Germany.
Zentralbl Pathol. 1994 Nov;140(4-5):357-62.
Growth factors and their receptors may be involved in initiation and progression of atherosclerotic intima changes. In this study, sections of human arteries in different stages of atherosclerosis were investigated for cellular expression of PDGF B, PDGF beta receptors and IGF I receptors. The applied immunohistochemical approach detected IGF I receptor synthesis in endothelial cells of atherosclerotic vessels. A possible role in atherogenesis may be seen in the control of IGF I transfer into subendothelial tissues. PDGF B chain production was observed in endothelial cells and macrophages in all stages of lesion development. The corresponding receptor for PDGF B (PDGF beta receptor) was expressed by transformed smooth muscle cells within the thickened intima from the stage of macrophage infiltration onwards. These results support the thesis that locally produced PDGF acts as a mitogen on smooth muscle cells and may promote proliferation during atherogenesis.
生长因子及其受体可能参与动脉粥样硬化内膜变化的起始和进展。在本研究中，对处于动脉粥样硬化不同阶段的人体动脉切片进行了血小板衍生生长因子B（PDGF B）、血小板衍生生长因子β受体和胰岛素样生长因子I（IGF I）受体的细胞表达研究。所应用的免疫组织化学方法检测到动脉粥样硬化血管内皮细胞中有IGF I受体合成。IGF I向血管内膜下组织的转运控制可能在动脉粥样硬化形成中发挥作用。在病变发展的所有阶段，在内皮细胞和巨噬细胞中均观察到PDGF B链的产生。从巨噬细胞浸润阶段开始，增厚内膜内的转化平滑肌细胞表达PDGF B的相应受体（PDGFβ受体）。这些结果支持以下论点，即局部产生的PDGF对平滑肌细胞起有丝分裂原作用，并可能在动脉粥样硬化形成过程中促进增殖。
