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Crystal structure of C-T-C-T-C-G-A-G-A-G. Implications for the structure of the Holliday junction.

作者信息

Goodsell D S, Grzeskowiak K, Dickerson R E

机构信息

Department of Chemistry and Biochemistry, University of California, Los Angeles 90024.

出版信息

Biochemistry. 1995 Jan 24;34(3):1022-9. doi: 10.1021/bi00003a037.

DOI:10.1021/bi00003a037
PMID:7827018
Abstract

The structure of the B-DNA decamer of sequence C-T-C-T-C-G-A-G-A-G shows a crossed arrangement of helices in the C2 crystal lattice. This is the fourth example of a crossed arrangement of B-DNA oligomers in a crystal, and in spite of the fact that each of these four crystallizes in a different lattice, all have nearly identical structures at the crossing contact. This ubiquitous crossing arrangement may be used to generate a structure for the Holliday junction that is fully consistent with the available physical data.

摘要

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