Persson I, Adami H O, McLaughlin J K, Naessén T, Fraumeni J F
Department of Obstetrics and Gynecology, University Hospital, Uppsala, Sweden.
Cancer Causes Control. 1994 Nov;5(6):523-8. doi: 10.1007/BF01831380.
To test the hypothesis that osteoporosis, which results partly from long-term estrogen deficiency, is associated with a lowered risk of breast and endometrial cancer, a population-based cohort study was performed in Sweden. Some 18,000 women were followed through record-linkages after a first hip fracture, on average for almost six years, to ascertain the incidence of breast and endometrial cancer. Expected numbers were derived from the general population. Overall, 253 cases of breast cancer were observed cf 300 expected (standardized incidence ratio [SIR] = 0.84; 95 percent confidence interval [CI] = 0.74-0.95). Forty-eight cases of endometrial cancer were found cf 55 expected (SIR = 0.87, CI = 0.54-1.16). There was no clearcut pattern of breast cancer risk by age at diagnosis of hip fracture, follow-up time, or calendar period. Our results are consistent with the a priori hypothesis that long-term estrogen deficiency is associated with a reduced risk of developing breast cancer as well as endometrial cancer.
为验证骨质疏松症（部分由长期雌激素缺乏所致）与乳腺癌和子宫内膜癌风险降低相关这一假说，在瑞典开展了一项基于人群的队列研究。约18000名女性在首次髋部骨折后通过记录链接进行随访，平均随访近6年，以确定乳腺癌和子宫内膜癌的发病率。预期病例数来自普通人群。总体而言，观察到253例乳腺癌病例，预期为300例（标准化发病率[SIR]=0.84；95%置信区间[CI]=0.74 - 0.95）。发现48例子宫内膜癌病例，预期为55例（SIR = 0.87，CI = 0.54 - 1.16）。在髋部骨折诊断时的年龄、随访时间或日历时间段方面，未发现乳腺癌风险的明确模式。我们的结果与长期雌激素缺乏与乳腺癌和子宫内膜癌发病风险降低相关的先验假说一致。
