Elkind Y, Nir B, Weller J I
Faculty of Agriculture, Hebrew University, Rehovot, Israel.
Comput Appl Biosci. 1994 Sep;10(5):513-7. doi: 10.1093/bioinformatics/10.5.513.
Consistent parameter estimates of quantitative trait loci linked to genetic markers can be derived by maximum likelihood methodology. For many experimental designs of interest, parameter estimates and their standard errors can be obtained by program LE of BMDP, which uses the Newton-Raphson method of iteration. Program LE was tested on data simulated for a backcross between two inbred lines. A single quantitative trait locus linked to either one or two genetic markers was simulated. Convergence was rapid, and computing and programming time were insignificant. All parameter estimates were within the expected bounds. Many different designs can be readily analyzed.
与遗传标记相关的数量性状位点的一致参数估计可以通过最大似然法得出。对于许多感兴趣的实验设计，参数估计及其标准误差可以通过BMDP的LE程序获得，该程序使用牛顿-拉弗森迭代法。LE程序在为两个近交系之间的回交模拟的数据上进行了测试。模拟了与一个或两个遗传标记相关的单个数量性状位点。收敛速度很快，计算和编程时间微不足道。所有参数估计都在预期范围内。许多不同的设计都可以很容易地进行分析。
