Hamilton G S, Kennedy T G
Department of Physiology, University of Western Ontario, London, Canada.
Can J Physiol Pharmacol. 1994 Jul;72(7):711-5. doi: 10.1139/y94-101.
Uterine vascular permeability (VP) was assessed after unilateral intrauterine injection of sesame oil to rats given either optimal sensitization for the decidual cell reaction or one of several forms of suboptimal sensitization. The study was intended to determine the relationship between changes in uterine VP and imminent endometrial decidualization. Uterine VP was estimated by the rate at which the uterine volume of distribution of i.v. injected 125I-labeled albumin approached the uterine extracellular fluid volume (ECFV). When ideal sensitization was provided, uterine VP was significantly greater in stimulated than nonstimulated horns at 4, 8, 16, and 32 h after stimulation (p < 0.05). Maximum VP in stimulated horns occurred at 8 h, with the time for the 125I-labeled albumin volume to reach half the uterine ECFV (t1/2) estimated to be 30 min. Different types of sensitization resulted in different levels of uterine VP in stimulated and nonstimulated horns, with maximal VP occurring in stimulated horns of rats that had previously received optimal sensitization for decidualization. We conclude that endometrial decidualization is preceded by significant increases in uterine VP and that optimal sensitization promotes an optimal VP response.
对给予蜕膜细胞反应最佳致敏或几种次优致敏形式之一的大鼠，在单侧子宫内注射芝麻油后评估子宫血管通透性（VP）。该研究旨在确定子宫VP变化与即将发生的子宫内膜蜕膜化之间的关系。子宫VP通过静脉注射125I标记白蛋白的子宫分布容积接近子宫细胞外液容积（ECFV）的速率来估计。当给予理想致敏时，在刺激后4、8、16和32小时，刺激侧子宫的VP显著高于未刺激侧（p < 0.05）。刺激侧子宫的最大VP出现在8小时，125I标记白蛋白容积达到子宫ECFV一半的时间（t1/2）估计为30分钟。不同类型的致敏导致刺激侧和未刺激侧子宫VP水平不同，最大VP出现在先前接受蜕膜化最佳致敏的大鼠的刺激侧子宫。我们得出结论，子宫内膜蜕膜化之前子宫VP显著增加，并且最佳致敏促进最佳VP反应。
