Sei H, Kiuchi T, Chang H Y, Seno H, Sano A, Morita Y
Department of Physiology, School of Medicine, University of Tokushima, Japan.
Chronobiol Int. 1994 Oct;11(5):293-300. doi: 10.3109/07420529409057245.
We have studied the effects of an 8-h advance of the environmental light-dark (LD) cycle on the sleep-wake rhythm in the rat. Electroencephalograms and electromyograms were recorded simultaneously on chart paper through a two-channel telemetry system for 3 days before phase shift (baseline) and 8 days during and after phase shift. Phase advance of the LD cycle led to an increase in both non-rapid eye movement (NREM) and REM sleep. The amount of NREM sleep in the light period correlated positively with that in the preceding dark period for 4 days after phase advance. The duration of REM sleep in the light period correlated negatively with that in the preceding dark period. The results suggest that homeostatic control of the amount of NREM sleep between the preceding dark period and the following light period is disturbed by phase advance of the LD cycle.
我们研究了环境明暗（LD）周期提前8小时对大鼠睡眠-觉醒节律的影响。通过双通道遥测系统在相移前3天（基线期）以及相移期间和之后的8天，同时在记录纸上记录脑电图和肌电图。LD周期的提前相移导致非快速眼动（NREM）睡眠和快速眼动（REM）睡眠均增加。相移后4天，光照期的NREM睡眠量与前一个暗期的NREM睡眠量呈正相关。光照期的REM睡眠时长与前一个暗期的REM睡眠时长呈负相关。结果表明，LD周期的提前相移扰乱了前一个暗期与随后光照期之间NREM睡眠量的稳态控制。
