Wexler D B, Moore-Ede M C
Am J Physiol. 1985 Mar;248(3 Pt 2):R353-62. doi: 10.1152/ajpregu.1985.248.3.R353.
To investigate the relationship between circadian rhythms of body temperature and sleep-wake stages, four squirrel monkeys were prepared for unrestrained monitoring of temperature, locomotor activity, electroencephalogram, electroculogram, and electromyogram. Continuous records for each animal were made for several 12-h light-dark (LD) cycles and then after a few days in constant illumination (LL). All animals maintained consolidated sleep-wake cycles and had a longer circadian period (mean 24.7 h) in LL than in LD (mean 24.1 h). The increased period reflected greater time per circadian cycle spent awake in LL (mean 14.0 h) than in LD (mean 12.8 h). Total night NREM sleep was less in LL (mean 6.5 h) than in LD (mean 8.2 h). Sleep onset occurred at later phases in LL (187 +/- 6 degrees) than in LD (170 +/- 2 degrees). Because the circadian phase measure of NREM sleep was unchanged between LD and LL conditions, the difference in sleep onsets reflected balanced changes in NREM circadian waveforms. Wake-up phases were the same in both conditions (mean 342 degrees). In summary, during free run squirrel monkeys maintain a stable consolidated circadian sleep-wake cycle with a period greater than 24 h, but they exhibit only minimal internal phase restructuring.
为了研究体温昼夜节律与睡眠-觉醒阶段之间的关系，对4只松鼠猴进行了准备，以无限制地监测体温、运动活动、脑电图、眼电图和肌电图。对每只动物进行连续记录，记录几个12小时明暗（LD）循环，然后在持续光照（LL）下记录几天后的数据。所有动物都维持着巩固的睡眠-觉醒周期，并且在LL中的昼夜周期（平均24.7小时）比在LD中（平均24.1小时）更长。周期的增加反映了每个昼夜周期在LL中清醒的时间（平均14.0小时）比在LD中（平均12.8小时）更长。LL中总的夜间非快速眼动睡眠（平均6.5小时）比LD中（平均8.2小时）少。睡眠开始在LL中（187±6度）比在LD中（170±2度）发生在更晚的阶段。因为在LD和LL条件下非快速眼动睡眠的昼夜相位测量没有变化，睡眠开始的差异反映了非快速眼动昼夜波形的平衡变化。两种条件下的唤醒阶段相同（平均342度）。总之，在自由运行期间，松鼠猴维持着一个稳定的巩固的昼夜睡眠-觉醒周期，其周期大于24小时，但它们仅表现出最小程度的内部相位重组。
