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[精神分裂症患者的出生季节。突尼斯住院人群的回顾性研究]

[Seasons of birth of schizophrenic patients. Retrospective study of a hospitalized population in Tunisia].

作者信息

Khiari G, Cheour M, Ben Nasr S, Bouzid R, Tabbane K, Douki S

出版信息

Encephale. 1994 Sep-Oct;20(5):473-7.

PMID:7828509
Abstract

Epidemiological research concerning the seasons of births of schizophrenics show for the greatest part that there's an excess of births in winter and in the beginning of spring. Research about the environmental theories of schizophrenia suggest that there would exist one or many seasonal environmental factors affecting the foetus and the neonate, and which would be likely to increase the risk of a subsequent development of schizophrenia. As no research concerning this subject have been published so far in Africa, the writers propose to study the distribution of births of a population of schizophrenics born in Tunisia in comparison to the general population and to compare it to a group of patients hospitalized because of major affective disorders. The results achieved show a significant decrease in the number of schizophrenics births during the third trimester and an excess of births during the month of october, the risk being greater in the case of disorganized schizophrenia. The greater risk for people born in october to develop subsequently schizophrenia is not found in the case of major affective disorders but it is found rather in the case of schizo-affective disorders. More over, we notice a decrease in the number of births during the month of July for the patients presenting major affective disorders and for those presenting schizo-affective disorders. Results seem to demonstrate that there would exist seasonal environmental factors specific to North Africa which are likely to affect the subsequent appearance of schizophrenic disorders. A particular interest should be given to viral infectious to enteroviruses which are responsible for summer diarrhea in Tunisia.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

关于精神分裂症患者出生季节的流行病学研究大多表明,冬季和初春出生的人数过多。关于精神分裂症环境理论的研究表明,可能存在一个或多个季节性环境因素影响胎儿和新生儿,并可能增加随后患精神分裂症的风险。由于目前在非洲尚未发表有关该主题的研究,作者建议研究突尼斯出生的精神分裂症患者群体的出生分布情况,并与普通人群进行比较,同时与因重度情感障碍住院的一组患者进行比较。研究结果显示,精神分裂症患者在妊娠晚期出生的人数显著减少,而10月份出生人数过多,在紊乱型精神分裂症患者中风险更高。10月份出生的人随后患精神分裂症的风险在重度情感障碍患者中未发现,但在精神分裂情感障碍患者中更为常见。此外,我们注意到,患有重度情感障碍和精神分裂情感障碍的患者在7月份出生人数减少。结果似乎表明,北非可能存在特定的季节性环境因素,这些因素可能会影响精神分裂症的后续发病。应特别关注导致突尼斯夏季腹泻的肠道病毒等病毒感染。(摘要截选至250字)

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