Boezen H M, Schouten J P, Postma D S, Rijcken B
Dept Epidemiology and Statistics, University Hospital, Groningen, The Netherlands.
Eur Respir J. 1994 Oct;7(10):1814-20. doi: 10.1183/09031936.94.07101814.
Peak expiratory flow (PEF) variability can be considered as an index of bronchial lability. Population studies on PEF variability are few. The purpose of the current paper is to describe the distribution of PEF variability in a random population sample of adults with a wide age range (20-70 yrs), and to assess relationships to age, gender and smoking habits. PEF data were collected in 511 participants of the Dutch part of the European Community Respiratory Health Survey. A training effect was found, absolute PEF values on the first measurement day being significantly lower. Females had greater PEF variability (adjusted for age, height and pack-years) and lower absolute PEFs than males. The mean within-day variation (amplitude % mean) was 3.66% (SD 2.03%), whereas the mean day-to-day variation was relatively small: 0.08% (SD 1.53%). Absolute PEFs were lower and amplitude % mean were significantly higher in older age groups. Smoking was significantly associated with lower mean PEFs and greater amplitude % mean. We observed lower mean values of the amplitude % mean than other investigators, possibly related to lower frequency of PEF recording (twice daily). We conclude that PEF and PEF variability have a normal or log-normal distribution. When studying PEF variability, age, gender and smoking habits should be taken into account.
呼气峰值流速（PEF）变异性可被视为支气管易激性的一个指标。关于PEF变异性的人群研究较少。本文的目的是描述在一个年龄范围广泛（20 - 70岁）的成年随机人群样本中PEF变异性的分布情况，并评估其与年龄、性别和吸烟习惯的关系。PEF数据收集自欧洲共同体呼吸健康调查荷兰部分的511名参与者。发现存在训练效应，第一天测量的绝对PEF值显著更低。女性比男性具有更大的PEF变异性（经年龄、身高和吸烟包年数校正）且绝对PEF更低。日内平均变异（幅度%均值）为3.66%（标准差2.03%），而日间平均变异相对较小：0.08%（标准差1.53%）。老年组的绝对PEF更低且幅度%均值显著更高。吸烟与更低的平均PEF以及更大的幅度%均值显著相关。我们观察到幅度%均值的平均值低于其他研究者，这可能与PEF记录频率更低（每日两次）有关。我们得出结论，PEF和PEF变异性呈正态或对数正态分布。在研究PEF变异性时，应考虑年龄、性别和吸烟习惯。
