Rossi G P, Pavan E, Chiesura-Corona M, Rea F, Poletti A, Pessina A C
Institute of Clinical Medicine, University of Padova, Italy.
Eur Respir J. 1994 Oct;7(10):1893-8. doi: 10.1183/09031936.94.07101893.
Bronchocentric granulomatosis (BCG) is a rare chronic granulomatous lung disease that leads to destruction of the airway walls. It has been observed in association with various conditions, but never, so far, been reported to involve the central nervous system. We report a case of histologically confirmed pulmonary bronchocentric granulomatosis temporally associated with a partial central diabetes insipidus (CDI). Although the pathological basis of the posterior pituitary gland involvement was not ascertained, the temporal association of bronchocentric granulomatosis and central diabetes insipidus, as well as the fact that corticosteroid treatment provided stable remission of both conditions after a 10 month follow-up, strongly suggest that central diabetes insipidus was aetiologically related to bronchocentric granulomatosis in this patient.
支气管中心性肉芽肿病（BCG）是一种罕见的慢性肉芽肿性肺病，可导致气道壁破坏。它已被观察到与多种情况相关，但迄今为止从未有报道累及中枢神经系统。我们报告一例经组织学证实的肺支气管中心性肉芽肿病，其在时间上与部分性中枢性尿崩症（CDI）相关。尽管未确定垂体后叶受累的病理基础，但支气管中心性肉芽肿病与中枢性尿崩症在时间上的关联，以及皮质类固醇治疗在10个月的随访后使两种情况均获得稳定缓解这一事实，强烈提示该患者的中枢性尿崩症在病因上与支气管中心性肉芽肿病相关。
