Hunt G M, Poulton A
Urology Department, Addenbrooke's Hospital, Cambridge, UK.
Dev Med Child Neurol. 1995 Jan;37(1):19-29. doi: 10.1111/j.1469-8749.1995.tb11929.x.
This study summarises the long-term results of non-selective treatment of open spina bifida. Every member of a consecutive series of 117 cases was ascertained 22 to 28 years after closure of the back. 56 of the cohort had died. The condition of the 61 survivors ranged from normal to severe disability. Only 33 of the survivors were capable of living independently, 11 required supervision and some help, and 17 needed daily care which was generally provided by the parents. The two main determinants of disability and dependency were the extent of the neurological deficit and IQ. Improvements in the management of patients with open spina bifida have greatly reduced mortality, but they are less likely to influence long-term disability since that is dependent on the severity of the neurological deficit.
本研究总结了开放性脊柱裂非选择性治疗的长期结果。在连续的117例患者系列中，每一位患者均在背部闭合后22至28年进行了随访。该队列中有56人死亡。61名幸存者的状况从正常到严重残疾不等。只有33名幸存者能够独立生活，11人需要监督和一些帮助，17人需要日常护理，通常由父母提供。残疾和依赖的两个主要决定因素是神经功能缺损的程度和智商。开放性脊柱裂患者管理方面的改善已大大降低了死亡率，但它们不太可能影响长期残疾，因为这取决于神经功能缺损的严重程度。
