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Nerve growth factor receptor immunostaining suggests an extrinsic origin for hypertrophic nerves in Hirschsprung's disease.

作者信息

Kobayashi H, O'Briain D S, Puri P

机构信息

Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland.

出版信息

Gut. 1994 Nov;35(11):1605-7. doi: 10.1136/gut.35.11.1605.

DOI:10.1136/gut.35.11.1605
PMID:7828981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1375620/
Abstract

The expression of nerve growth factor receptor in colon from 20 patients with Hirshsprung's disease and 10 controls was studied immunohistochemically. The myenteric and submucous plexuses in the ganglionic bowel and hypertrophic nerve trunks in the aganglionic bowel displayed strong expression of nerve growth factor receptor. The most important finding was the identical localisation of nerve growth factor receptor immunoreactivity on the perineurium of both hypertrophic nerve trunks in Hirshsprung's diseases, and of normal extrinsic nerves, seen as a thick ring surrounding the nerve trunks. This suggests that the hypertrophic nerve trunks are of extrinsic origin and that nerve growth factor receptor plays a role in their development and maintenance.

摘要

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2
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3
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本文引用的文献

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An immunohistochemical study of neurofilament and microtubule-associated Tau protein in the enteric innervation in Hirschsprung's disease.先天性巨结肠症肠内神经支配中神经丝和微管相关Tau蛋白的免疫组织化学研究
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Lack of expression of NADPH-diaphorase and neural cell adhesion molecule (NCAM) in colonic muscle of patients with Hirschsprung's disease.先天性巨结肠症患者结肠肌层中烟酰胺腺嘌呤二核苷酸磷酸黄递酶和神经细胞黏附分子（NCAM）的表达缺失。
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Gut. 2001 Aug;49(2):220-6. doi: 10.1136/gut.49.2.220.
先天性巨结肠症患者盆腔脏器神经支配的组织学和胚胎学研究。
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An immunohistochemical study of the enteric neural plexi in Hirschsprung's disease.
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Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): distribution, morphology, and colocalization with cholinergic enzymes.非人灵长类动物（僧帽猴）中神经生长因子受体免疫反应性：分布、形态以及与胆碱能酶的共定位
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