编码通用转录因子TFIIE两个亚基的人类基因的定位
Localization of the human genes encoding the two subunits of general transcription factor TFIIE.
作者信息
Purrello M, Di Pietro C, Rapisarda A, Motta S, Pavone L, Grzeschik K H, Sichel G
机构信息
Istituto di Biologia generale, Università di Catania, Italy.
出版信息
Genomics. 1994 Sep 1;23(1):253-5. doi: 10.1006/geno.1994.1488.
TFIIE is a general transcription factor for class II genes composed of two types of subunits, a large one of 56 kDa and a small of 34 kDa. By Southern analysis at high and at low stringency of a panel of mouse/human hybrid cell lines and by in situ chromosomal hybridization, we have demonstrated that both polypeptides are encoded by genes that are single copy in the human genome and are localized at 3q13-q21 and at 8p12, respectively. A TaqI RFLP (heterozygosity index of 0.07) was detected at the locus for the 56-kDa subunit.
TFIIE是一种II类基因的通用转录因子，由两种亚基组成，一种是56 kDa的大亚基，另一种是34 kDa的小亚基。通过对一组小鼠/人类杂交细胞系进行高严谨度和低严谨度的Southern分析以及原位染色体杂交，我们已经证明这两种多肽均由人类基因组中为单拷贝的基因编码，且分别定位于3q13 - q21和8p12。在56 kDa亚基的基因座处检测到一个TaqI限制性片段长度多态性（杂合度指数为0.07）。
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