Cannon-Albright L A, Goldgar D E, Neuhausen S, Gruis N A, Anderson D E, Lewis C M, Jost M, Tran T D, Nyguen K, Kamb A
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84108.
Genomics. 1994 Sep 1;23(1):265-8. doi: 10.1006/geno.1994.1491.
A familial melanoma susceptibility locus (MLM) was identified on the short arm of chromosome 9 in a set of Utah and Texas kindreds. Subsequent confirmation was reported for a set of 26 Australian kindreds, a set of 7 Dutch kindreds, and a set of 13 NIH melanoma kindreds. The original localization report placed the locus near the IFNA-D9S126 interval on chromosome 9p. We report further localization using D9S171 and a newly developed marker, D9S736, both of which lie in the IFNA-D9S126 interval. Analysis of this set of kindreds places the melanoma susceptibility locus in a 2-cM region that is proximal to D9S736 and distal to D9S171.
