Zygraich N
Dev Biol Stand. 1976;33:141-50.
Live influenza virus vaccines should meet the following criteria: attenuation, immunogenicity, lack of spread, genetic stability, production in a suitable cell substrate, and stability during storage. In addition, they should be able to induce a wide antigenic protection. These various aspects will be discussed with reference to the "Alice" strain of live influenza A virus, which possesses all the properties for a good live attenuated virus vaccine.
减毒、免疫原性、无传播性、遗传稳定性、在合适的细胞基质中生产以及储存期间的稳定性。此外，它们应能够诱导广泛的抗原性保护。将参照甲型流感活病毒的“爱丽丝”毒株讨论这些不同方面，该毒株具备成为一种优质减毒活病毒疫苗的所有特性。
