Delem A
Dev Biol Stand. 1976;33:226-33.
Groups of three ferrets were inoculated with a live influenza vaccine ("Alice" strain) and the degree of protection afforded against a challenge inoculation was measured by several parameters. After vaccination, virus excretion was studied and the genetic characteristics of the virus isolates were investigated. After 5-8 weeks, the challenge inoculations were performed with antigenic drifts of the H3N2 virus: A/Dunedin/4/73 (Port-Chalmers-like), A/England/635/74 and A/Scotland/840/74. The following parameters of infection were evaluated: temperature rises, clinical symptoms, viral excretion, serological responses and increases in the nasal protein contents (Potter et. al(1972). Immunity to influenza in ferrets. I. Response to live and killed virus. Brit. J. Exp. Path., 53, 153-167.) A very high degree of protection was observed in the immunized animals.
将三只雪貂分为一组，接种活流感疫苗（“爱丽丝”毒株），并通过几个参数来衡量其对攻毒接种所提供的保护程度。接种疫苗后，研究病毒排泄情况，并调查病毒分离株的基因特征。5至8周后，用H3N2病毒的抗原漂移株进行攻毒接种：A/达尼丁/4/73（类似波特 - 查尔默斯株）、A/英格兰/635/74和A/苏格兰/840/74。评估了以下感染参数：体温升高、临床症状、病毒排泄、血清学反应以及鼻腔蛋白质含量增加（波特等人（1972年）。雪貂对流感的免疫力。I. 对活病毒和灭活病毒的反应。《英国实验病理学杂志》，53，153 - 167）。在免疫动物中观察到了非常高的保护程度。
