青春期前痤疮：雄激素过多的皮肤标志物？
Prepubertal acne: a cutaneous marker of androgen excess?
作者信息
De Raeve L, De Schepper J, Smitz J
机构信息
Department of Dermatology, Free University of Brussels, Belgium.
出版信息
J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):181-4. doi: 10.1016/0190-9622(95)90122-1.
BACKGROUND
Early-onset acne before obvious signs of puberty is an uncommon phenomenon.
OBJECTIVE
The aim of this study was to determine if prepubertal acne is associated with an excess of androgens.
METHODS
Basal and adrenocorticotrophic hormone-stimulated plasma androgen levels were measured and bone age was determined in 15 children with early-onset acne.
RESULTS
A late-onset adrenogenital syndrome caused by 21-hydroxylase deficiency was diagnosed in two children. These children had early pubic hair development and advanced bone maturation. Heterozygosity for 21-hydroxylase deficiency was found in three other children.
CONCLUSION
We recommend hormonal evaluation in children with prepubertal acne, especially those with associated advanced bone maturation and early pubarche.
背景
在青春期明显体征出现之前的早发性痤疮是一种罕见现象。
目的
本研究的目的是确定青春期前痤疮是否与雄激素过多有关。
方法
测量了15例早发性痤疮患儿的基础及促肾上腺皮质激素刺激后的血浆雄激素水平，并确定了骨龄。
结果
两名儿童被诊断为由21 - 羟化酶缺乏引起的迟发性肾上腺生殖综合征。这些儿童有早期阴毛发育和骨成熟提前。另外三名儿童发现有21 - 羟化酶缺乏的杂合子状态。
结论
我们建议对青春期前痤疮患儿进行激素评估，尤其是那些伴有骨成熟提前和青春期阴毛早现的患儿。
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