Parker T L, Zitelli J A
Shadyside Medical Center, Pittsburgh, PA 15232.
J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):233-6. doi: 10.1016/0190-9622(95)90132-9.
Dermatofibrosarcoma protuberans (DFSP) commonly recurs after standard surgical excision with a wide margin. No studies have been undertaken to objectively determine the appropriate surgical margins by measuring the extension of the subclinical tumor.
Our purpose was to measure the subclinical extent of tumor in 20 patients with DFSP to determine appropriate surgical margins.
We mapped the subclinical tumor extension with Mohs micrographic surgery and measured the surgical margins required to clear the tumor completely.
We found that a 2.5 cm surgical margin through the deep fascia (nonscalp) or periosteum (scalp) cleared all of the tumors. DFSP tumors that measured less than 2 cm were completely cleared with a 1.5 cm surgical margin. None of our patients had a recurrence of the tumor, and in 16 of 20 patients repairs were possible.
Our data support the use of Mohs surgery to excise DFSP with maximum conservation of tissue and a high cure rate.
隆突性皮肤纤维肉瘤(DFSP)在标准手术广泛切除后常复发。尚未开展研究通过测量亚临床肿瘤的范围来客观确定合适的手术切缘。
我们的目的是测量20例DFSP患者肿瘤的亚临床范围,以确定合适的手术切缘。
我们用莫氏显微外科手术描绘亚临床肿瘤的范围,并测量完全清除肿瘤所需的手术切缘。
我们发现,通过深筋膜(非头皮)或骨膜(头皮)2.5厘米的手术切缘可清除所有肿瘤。直径小于2厘米的DFSP肿瘤通过1.5厘米的手术切缘可完全清除。我们的患者均未出现肿瘤复发,20例患者中有16例可行修复。
我们的数据支持使用莫氏手术切除DFSP,以最大程度保留组织并提高治愈率。