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探索激光诱导击穿光谱作为莫氏显微外科术中一种潜在工具:一篇小型综述。

Exploring Laser-Induced Breakdown Spectroscopy as a Potential Tool in Mohs Micrography: A Mini Review.

作者信息

Singh Sandeep, Desai Rupak, Modi Mitul, Hussain Showket

机构信息

Neurology, Institute of Human Behavior and Allied Sciences (IHBAS), Delhi, India.

Research Coordinator, Atlanta Veterans Affairs Medical Center.

出版信息

Cureus. 2017 Nov 13;9(11):e1842. doi: 10.7759/cureus.1842.

DOI:10.7759/cureus.1842
PMID:29344436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5766351/
Abstract

Mohs micrographic surgery is the technique of surgically removing skin tumors by gradually excising thin layers and visualizing under a microscope till a tumor-free zone is obtained. During the surgical procedure, visible tumors are surgically removed. During the second stage, if tumor margins are clear with the positive specimen at depth, only depth cavitations need to be done without altering the tumor diameter. Defining the depth during this procedure is a major challenge due to the nonexistence of proper guidelines. Using the laser-induced breakdown spectroscopy (LIBS) technique, depth profiling can be performed precisely, preventing excessive tissue removal and reducing time consumption during the microscopic examination.

摘要

莫氏显微外科手术是一种通过逐步切除薄层皮肤肿瘤并在显微镜下观察直至获得无肿瘤区域来进行手术切除的技术。在手术过程中,肉眼可见的肿瘤会被手术切除。在第二阶段,如果肿瘤边缘与深部阳性标本边界清晰,则仅需进行深部空洞化处理,而不改变肿瘤直径。由于缺乏适当的指导方针,在此过程中确定深度是一项重大挑战。使用激光诱导击穿光谱(LIBS)技术,可以精确地进行深度剖析,避免过度切除组织,并减少显微镜检查期间的时间消耗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a323/5766351/5543c63f72df/cureus-0009-00000001842-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a323/5766351/5543c63f72df/cureus-0009-00000001842-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a323/5766351/5543c63f72df/cureus-0009-00000001842-i01.jpg

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本文引用的文献

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Suggested excisional margins for cutaneous malignant lesions based on Mohs micrographic surgery.基于Mohs 显微外科的皮肤恶性病变建议切除边界。
JAMA Facial Plast Surg. 2013 Sep-Oct;15(5):337-43. doi: 10.1001/jamafacial.2013.1011.
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Treatment of facial Basal cell carcinoma: a review.面部基底细胞癌的治疗:综述
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What is the best surgical margin for a Basal cell carcinoma: a meta-analysis of the literature.基底细胞癌的最佳手术切缘是什么:文献荟萃分析。
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Exploiting LIBS as a spectrochemical analytical technique in diagnosis of some types of human malignancies.利用 LIBS 作为一种光谱化学分析技术诊断人类某些类型的恶性肿瘤。
Talanta. 2010 Jul 15;82(2):495-501. doi: 10.1016/j.talanta.2010.04.064. Epub 2010 May 10.
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Zinc analysis in human skin by laser induced-breakdown spectroscopy.通过激光诱导击穿光谱法对人体皮肤进行锌分析。
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Detection of trace Al in model biological tissue with laser-induced breakdown spectroscopy.
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Comparison of trace element concentrations in cancerous and noncancerous human endometrial and ovary tissues.人类癌性和非癌性子宫内膜及卵巢组织中微量元素浓度的比较。
Int J Gynecol Cancer. 2007 Jan-Feb;17(1):220-8. doi: 10.1111/j.1525-1438.2006.00742.x.