Shigesato M, Hirasawa K, Takeda M, Doi K
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Lab Anim. 1994 Oct;28(4):330-4. doi: 10.1258/002367794780745146.
Characteristics of encephalomyocarditis (EMC) virus-induced testicular lesions were investigated in 4- and 8-week-old BALB/c male mice after intraperitoneal (i.p.) and intratesticular (left) (i.t.) inoculation of the D variant of EMC virus (EMC-D). Apart from variation in severity and incidence, the histopathological nature of the resultant testicular lesion was similar in all infected mice, and was characterized by degeneration and necrosis of germinal cells and spermatogonia with inflammatory infiltration. Almost all the inoculated left testes of the i.t. group developed marked lesions. In general, the virus titre in the testis and incidence of testicular lesions were higher in 4-week-old mice than in 8-week-old mice. In addition, testicular lesions developed earlier and with a higher incidence in the PBS-inoculated right testis of the i.t. group than in either testis of the i.p. group of the same age.
在4周龄和8周龄的BALB/c雄性小鼠腹腔内（i.p.）和睾丸内（左侧）（i.t.）接种脑心肌炎（EMC）病毒D变种（EMC-D）后，对EMC病毒诱导的睾丸病变特征进行了研究。除了严重程度和发病率存在差异外，所有感染小鼠所产生的睾丸病变的组织病理学性质相似，其特征为生殖细胞和精原细胞变性坏死并伴有炎症浸润。i.t.组几乎所有接种的左侧睾丸都出现了明显病变。总体而言，4周龄小鼠睾丸中的病毒滴度和睾丸病变发生率高于8周龄小鼠。此外，i.t.组接种PBS的右侧睾丸比同年龄i.p.组的任一睾丸更早出现且更频繁地出现睾丸病变。
