Response of guinea pigs and hamsters to experimental infection with Mycoplasma pneumoniae.

In an effort to further delineate the mechanism of infection and pathogenicity of Mycoplasma pneumoniae infections, the hamster and guinea pigs were used as experimental models. These animals were chosen because of previous experience. The local antibody response in addition to organism growth patterns were examined in detail. Histological examination was carried out to determine the pathological lesions which occur. The significance of these findings is discussed.