Vanderwinkel E, De Vlieghere M, Fontaine M, Charles D, Denamur F, Vandevoorde D, De Kegel D
J Bacteriol. 1976 Sep;127(3):1389-99. doi: 10.1128/jb.127.3.1389-1399.1976.
Mutants of Escherichia coli defective in the regulation of the fatty acids beta oxidation pathway show an ultrastructural deficiency in septum formation at high growth rate. Several independent pairs of parent and mutant strains have been analyzed biochemically. Each parent strain displays a well-defined pattern of cellular phospholipids, which varies with the growth conditions. High ratios of phosphatidylglycerol to cardiolipin characterize fast-growth conditions. None of the mutant strains, although they grow in mass nearly as rapidly as their respective parents, can reach these high ratios. The beta oxidation pathway regulatory mutation leads to an increased turnover of the glycerol moieties of these phospholipids in the inner as well as in the outer cell membrane.
在脂肪酸β氧化途径调控方面存在缺陷的大肠杆菌突变体，在高生长速率下隔膜形成出现超微结构缺陷。已对几对独立的亲本菌株和突变体菌株进行了生化分析。每个亲本菌株都呈现出明确的细胞磷脂模式，该模式随生长条件而变化。磷脂酰甘油与心磷脂的高比例是快速生长条件的特征。尽管所有突变体菌株在质量上几乎与各自的亲本菌株生长得一样快，但它们都无法达到这些高比例。β氧化途径调控突变导致这些磷脂的甘油部分在细胞内膜和外膜中的周转率增加。
