Maloy S R, Bohlander M, Nunn W D
J Bacteriol. 1980 Aug;143(2):720-5. doi: 10.1128/jb.143.2.720-725.1980.
Mutants of Escherichia coli K-12 constitutive for the synthesis of the enzymes of fatty acid degradation (fadR) have elevated levels of the glyoxylate shunt enzymes, isocitrate lyase and malate synthase. A temperature-sensitive fadR strain has high levels of glyoxylate shunt enzymes when grown at elevated temperatures but has low, inducible levels of glyoxylate shunt enzymes when grown at low temperatures. The increased activity of glyoxylate shunt enzymes did not appear to be due to the degradation of intracellular fatty acids in fadR strains or differences in allosteric effectors in fadR versus fadR+ strains. These studies suggest that the fadR gene product may be involved in the regulation of the glyoxylate operon.
大肠杆菌K-12中脂肪酸降解酶合成组成型突变体（fadR）的乙醛酸循环酶、异柠檬酸裂解酶和苹果酸合酶水平升高。一个温度敏感型fadR菌株在高温下生长时乙醛酸循环酶水平很高，但在低温下生长时乙醛酸循环酶水平较低且可诱导。乙醛酸循环酶活性的增加似乎不是由于fadR菌株中细胞内脂肪酸的降解或fadR与fadR+菌株中变构效应物的差异。这些研究表明，fadR基因产物可能参与乙醛酸操纵子的调控。
