Korzh E V, Valutsina V M, Noreĭko S B
Lik Sprava. 1994 May-Jun(5-6):46-9.
There have been established opposite reactions in the cardiovascular system during formation of dust-induced pathology of lungs: a common finding in patients with pneumoconiosis is alterations in the left heart, while in chronic dust bronchitis the same is true of the right heart. In the authors' opinion, different states of pulmonary surfactant in the above conditions account for this observation. Inhibition of synthesis of the pulmonary surfactant associated with the development of the blood and tissue phospholipid deficiency makes for the evolution of atherosclerosis in patients with pneumoconiosis while enhancement of the phospholipid production by the lungs accompanied by elevation of their blood content is an important factor inhibiting the processes of atherogenesis in patients with dust bronchitis.
在肺部粉尘诱导性病变形成过程中，心血管系统会出现相反的反应：尘肺病患者的一个常见发现是左心改变，而在慢性粉尘性支气管炎中，右心也会出现同样的情况。作者认为，上述情况下肺表面活性物质的不同状态可以解释这一现象。与血液和组织磷脂缺乏相关的肺表面活性物质合成抑制会导致尘肺病患者动脉粥样硬化的发展，而肺部磷脂生成增加并伴有血液中磷脂含量升高是抑制粉尘性支气管炎患者动脉粥样硬化进程的一个重要因素。
