患有人格障碍和抑郁症的阿片类药物成瘾者的兄弟姐妹中的α-1和2肾上腺素能受体敏感性降低。

Alpha-1- and 2-adrenoceptor subsensitivity in siblings of opioid addicts with personality disorders and depression.

作者信息

Gerra G, Caccavari R, Marcato A, Zaimovic A, Avanzini P, Monica C, Mutti A, Fontanesi B, Delsignore R, Brambilla F

机构信息

Centro Studi Farmacotossicodipendenze, SER.T., Parma, Italy.

出版信息

Acta Psychiatr Scand. 1994 Oct;90(4):269-73. doi: 10.1111/j.1600-0447.1994.tb01592.x.

DOI:10.1111/j.1600-0447.1994.tb01592.x

PMID:7831997

Abstract

Noradrenergic receptor sensitivity of 16 healthy male siblings of heroin addicts and of 8 age and sex-matched controls was examined by administering a clonidine stimulation test and by measuring the resulting growth hormone (GH) (alpha-2-adrenoceptors) and beta-endorphin (beta-endorphin) (alpha-1-adrenoceptors) responses. Siblings were divided into two groups: A = siblings of heroin addicts with personality disorders and high aggressivity and B = siblings of heroin addicts without mental disorders. The GH and beta-endorphin responses to clonidine were blunted in group A subjects compared with controls and normal in group B.

摘要

通过给予可乐定刺激试验并测量由此产生的生长激素（GH）（α-2肾上腺素能受体）和β-内啡肽（β-内啡肽）（α-1肾上腺素能受体）反应，对16名海洛因成瘾者的健康男性兄弟姐妹以及8名年龄和性别匹配的对照者的去甲肾上腺素能受体敏感性进行了检测。这些兄弟姐妹被分为两组：A组 = 患有精神障碍和高攻击性的海洛因成瘾者的兄弟姐妹，B组 = 没有精神障碍的海洛因成瘾者的兄弟姐妹。与对照组相比，A组受试者对可乐定的GH和β-内啡肽反应减弱，而B组则正常。