有或无前驱注意缺陷多动障碍及品行障碍的海洛因成瘾者的α2肾上腺素能受体敏感性

Alpha-2-adrenoceptor sensitivity in heroin addicts with and without previous attention deficit disorder/hyperactivity and conduct disorder.

作者信息

Gerra G, Caccavari R, Fontanesi B, Delsignore R, Fertonani-Affini G, Marcato A, Maestri D, Avanzini P, Perna G, Brambilla F

机构信息

Drug Addiction Service, Health Unit (USL n4), Parma, Italy.

出版信息

Neuropsychobiology. 1994;30(1):15-9. doi: 10.1159/000119129.

DOI:10.1159/000119129

PMID:7969853

Abstract

Growth hormone (GH) and beta-endorphin (beta-EP) responses to clonidine stimulation were examined in 18 male heroin addicts, 9 with and 9 without previous histories of attention deficit disorder with hyperactivity (ADD-H) and conduct disorder (CD). Ten psychophysically healthy volunteers were used as controls. ADD-H/CD addicts had blunted GH and beta-EP responses as compared to controls while those of non-ADD-H/CD addicts were normal. This suggests that postsynaptic adrenoceptor sensitivity is decreased and, possibly, that presynaptic noradrenaline secretion is increased in ADD-H/CD patients with heroin addiction.

摘要

对18名男性海洛因成瘾者进行了生长激素（GH）和β-内啡肽（β-EP）对可乐定刺激的反应检测，其中9名有注意缺陷多动障碍（ADD-H）和品行障碍（CD）病史，9名没有。10名身心健康的志愿者作为对照。与对照组相比，ADD-H/CD成瘾者的GH和β-EP反应迟钝，而非ADD-H/CD成瘾者的反应正常。这表明，患有海洛因成瘾的ADD-H/CD患者的突触后肾上腺素能受体敏感性降低，并且可能突触前去甲肾上腺素分泌增加。