Maghraoui S, Grossin M, Crickx B, Blanchet P, Belaïch S
Service de Dermatologie, CHU Xavier-Bichat, Paris.
Ann Dermatol Venereol. 1994;121(3):259-65.
Sixteen cases of acquired mid-dermal elastolysis have been reported in the literature. In 1977, Shelley identified this type of elastolysis as a separate entity and described three variants: post-inflammatory elastolysis with cutis laxa predominates in facial areas in African children. The initial inflammatory lesions are replaced by rough wrinkling of the skin; post-inflammatory elastolysis without cutis laxa; non-inflammatory elastolysis without cutis laxa as mid-dermal elastolysis. It is difficult nevertheless to classify certain cases reported in the literature. This would suggest that there is in reality a continuum of acquired elastolysis which could be classed according to a scale of decreasing initial inflammation. The non-inflammatory pole would represent mid-dermal elastolysis. The common features of the different types of elastolysis are dominated by the absence of a causative agent in most cases, unknown pathogenesis and the fact that the empirical treatments which have been used have been ineffective.
文献中已报道了16例获得性真皮中部弹性组织溶解症。1977年，雪莱将这种类型的弹性组织溶解症确定为一个独立的病症，并描述了三种变体：非洲儿童面部以皮肤松弛为主的炎症后弹性组织溶解症。最初的炎症性病变被皮肤粗糙起皱所取代；无皮肤松弛的炎症后弹性组织溶解症；无皮肤松弛的非炎症性弹性组织溶解症即真皮中部弹性组织溶解症。然而，对文献中报道的某些病例进行分类很困难。这表明实际上存在一系列获得性弹性组织溶解症，可根据初始炎症程度降低的程度进行分类。非炎症性极点代表真皮中部弹性组织溶解症。不同类型弹性组织溶解症的共同特征在大多数情况下表现为无致病因素、发病机制不明以及所用的经验性治疗无效。
