Lewis Kevan G, Bercovitch Lionel, Dill Sara W, Robinson-Bostom Leslie
Department of Dermatology, Brown Medical School-Rhode Island Hospital, Providence, RI 02903, USA.
J Am Acad Dermatol. 2004 Aug;51(2):165-85; quiz 186-8. doi: 10.1016/j.jaad.2004.03.016.
Elastic fibers in the extracellular matrix are integral components of dermal connective tissue. The resilience and elasticity required for normal structure and function of the skin are attributable to the network of elastic tissue. Advances in our understanding of elastic tissue physiology provide a foundation for studying the pathogenesis of elastic tissue disorders. Many acquired disorders are nevertheless poorly understood owing to the paucity of reported cases. Several acquired disorders in which loss of dermal elastic tissue produces prominent clinical and histopathologic features have recently been described, including middermal elastolysis, papular elastorrhexis, and pseudoxanthoma-like papillary dermal elastolysis, which must be differentiated from more well-known disorders such as anetoderma, acquired cutis laxa, and acrokeratoelastoidosis. Learning objective At the conclusion of this learning activity, participants should have an understanding of the similarities and differences between acquired disorders of elastic tissue that are characterized by a loss of elastic tissue.
细胞外基质中的弹性纤维是真皮结缔组织的重要组成部分。皮肤正常结构和功能所需的弹性和韧性归因于弹性组织网络。我们对弹性组织生理学认识的进展为研究弹性组织疾病的发病机制提供了基础。然而，由于报告病例稀少，许多后天性疾病仍了解不足。最近描述了几种后天性疾病，其中真皮弹性组织丧失会产生突出的临床和组织病理学特征，包括真皮中部弹性溶解、丘疹性弹性纤维破碎症和类假黄瘤性乳头状真皮弹性溶解，这些疾病必须与更知名的疾病如皮肤松弛症、获得性皮肤松弛症和肢端角化性弹性组织变性相鉴别。学习目标 在本学习活动结束时，参与者应了解以弹性组织丧失为特征的后天性弹性组织疾病之间的异同。
