Kim J M, Su W P
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
J Am Acad Dermatol. 1992 Feb;26(2 Pt 1):169-73.
We observed two patients who had mid dermal elastolysis with wrinkling.
We reviewed the pertinent features of the four cases reported in the literature and of our two cases. We also compared mid dermal elastolysis with other disorders of acquired elastolysis, such as postinflammatory elastolysis and cutis laxa, anetoderma, and (regular) cutis laxa.
Our two patients with mid dermal elastolysis with wrinkling were middle-aged, white women. Physical examination showed widespread wrinkling, erythematous patches (macules), and papules. Histologic examination showed patchy loss of elastic tissue limited to the mid dermis. In one of our patients, elastolytic skin lesions appeared on areas not covered by a two-piece swimsuit. She used to sunbathe frequently. In our other patient, skin lesions were also more prominent on exposed areas.
We speculate that sun exposure is one of the main causative factors of mid dermal elastolysis with wrinkling.
我们观察到两名患有真皮中层弹性组织溶解伴皱纹的患者。
我们回顾了文献报道的4例以及我们自己的2例患者的相关特征。我们还将真皮中层弹性组织溶解与其他获得性弹性组织溶解疾病进行了比较，如炎症后弹性组织溶解、皮肤松弛症、皮肤松弛症（普通型）和斑状萎缩。
我们的两名患有真皮中层弹性组织溶解伴皱纹的患者均为中年白人女性。体格检查显示广泛的皱纹、红斑（斑疹）和丘疹。组织学检查显示弹性组织片状缺失，局限于真皮中层。在我们的一名患者中，弹性组织溶解的皮肤病变出现在两件式泳衣未覆盖的部位。她过去经常日光浴。在我们的另一名患者中，皮肤病变在暴露部位也更为突出。
我们推测日晒是真皮中层弹性组织溶解伴皱纹的主要致病因素之一。
