Landgraf H, Vanselow B, Schulte-Huermann D, Mülmann M V, Bergau L
Department of Internal Medicine, University Hospital Frankfurt/M, Germany.
Aviat Space Environ Med. 1994 Oct;65(10 Pt 1):930-5.
In order to study pathological changes that might lead to deep vein thrombosis and pulmonary embolism in long-distance air travel passengers, 12 healthy volunteers were investigated during 4 simulated 12-h flights (day and night). The influence of repeated leg exercise was compared with constant sitting. Plasma viscosity, hematocrit, albumin, fluid balance, and lower leg swelling were measured. Rheological studies showed only circadian rhythm alterations. An average of 1150 ml fluid was retained, which correlated with an increase in body weight. The lower leg volume increase was significant, but not pathological. Periodic leg exercising showed no measurable preventive effects. These changes in healthy human volunteers are within physiological variations and are not sufficient to provide a definitive cause of venous thrombosis in healthy passengers. They do, however, suggest alterations produced by long-distance air travel that could intensify the risk of developing deep venous thrombosis in passengers with predisposing risk factors.
为研究长途航空旅客可能导致深静脉血栓形成和肺栓塞的病理变化，在4次模拟12小时航班（白天和夜间）期间对12名健康志愿者进行了调查。将重复腿部运动的影响与持续坐着的影响进行了比较。测量了血浆粘度、血细胞比容、白蛋白、液体平衡和小腿肿胀情况。流变学研究仅显示出昼夜节律改变。平均潴留1150毫升液体，这与体重增加相关。小腿体积增加显著，但并非病理性的。定期腿部运动未显示出可测量的预防效果。健康人类志愿者的这些变化在生理变异范围内，不足以成为健康乘客静脉血栓形成的确切原因。然而，它们确实提示了长途航空旅行所产生的变化，这些变化可能会增加具有易感风险因素的乘客发生深静脉血栓形成的风险。
