氟烷对新生儿睫状肌搏动频率的影响。

The effect of halothane on neonatal ciliary beat frequency.

作者信息

O'Callaghan C, Atherton M, Karim K, Gyi A, Langton J A, Zamudio I, Barry P

机构信息

Department of Child Health, University of Leicester, Leicester Royal Infirmary, United Kingdom.

出版信息

J Paediatr Child Health. 1994 Oct;30(5):429-31. doi: 10.1111/j.1440-1754.1994.tb00694.x.

DOI:10.1111/j.1440-1754.1994.tb00694.x

PMID:7833080

Abstract

The effect of a commonly used anaesthetic agent, halothane, on neonatal cilial function was determined. A nasal cilial sample was taken from 13 healthy, term, newborn infants. For 1 h, half of each sample was exposed to halothane and half to air. Cilial function was assessed by measuring beat frequency with a modified light transmission method. Cilial beat frequency was significantly slower in the cilia exposed to halothane, 9(s.d. 2.5)Hz, than to air, 12.9(s.d. 1.5)Hz. Decreased mucociliary clearance following halothane anaesthesia is due, at least in part, to a directly depressant effect of halothane on ciliated cells.

摘要

研究了常用麻醉剂氟烷对新生儿纤毛功能的影响。从13名健康足月新生儿中采集鼻纤毛样本。每个样本的一半暴露于氟烷1小时，另一半暴露于空气中。采用改良的光透射法通过测量摆动频率来评估纤毛功能。暴露于氟烷的纤毛摆动频率明显较慢，为9（标准差2.5）Hz，而暴露于空气的纤毛摆动频率为12.9（标准差1.5）Hz。氟烷麻醉后黏液纤毛清除功能下降至少部分是由于氟烷对纤毛细胞有直接抑制作用。