Martyn C N, Meade T W, Stirling Y, Barker D J
MRC Environmental Epidemiology Unit, Southampton General Hospital.
Br J Haematol. 1995 Jan;89(1):142-6. doi: 10.1111/j.1365-2141.1995.tb08920.x.
To examine the relation between fetal development and plasma concentrations of fibrinogen and factor VII in adult life we followed up 202 men and women, now aged around 50 years, who had been measured in detail at birth. Plasma concentrations of fibrinogen were related to weight and abdominal circumference at birth. In men, after adjustment for cigarette smoking and current obesity, plasma concentrations of fibrinogen fell by 0.12 g/l (95% CI 0.05-0.19) for each pound increase in birthweight and by 0.10 g/l (95% CI 0.03-0.17) for each inch increase in abdominal circumference. In contrast, analysis of the data for women showed no statistically significant relation between plasma fibrinogen concentration and weight or abdominal circumference at birth. No relation was seen between concentrations of factor VII and measurements made at birth in either sex. These findings suggest that, in men, reduced growth of the liver in fetal life has a long-term influence on fibrinogen metabolism.
为了研究胎儿发育与成年后血浆纤维蛋白原和凝血因子VII浓度之间的关系，我们对202名男女进行了随访，这些人现在年龄约为50岁，他们在出生时曾接受过详细测量。血浆纤维蛋白原浓度与出生时的体重和腹围有关。在男性中，在调整了吸烟和当前肥胖因素后，出生体重每增加一磅，血浆纤维蛋白原浓度下降0.12 g/l（95%可信区间0.05 - 0.19），腹围每增加一英寸，血浆纤维蛋白原浓度下降0.10 g/l（95%可信区间0.03 - 0.17）。相比之下，对女性数据的分析显示，血浆纤维蛋白原浓度与出生时的体重或腹围之间没有统计学上的显著关系。在任何性别中，凝血因子VII浓度与出生时的测量值之间均未发现关联。这些发现表明，在男性中，胎儿期肝脏生长受限对纤维蛋白原代谢具有长期影响。
