Roseboom T J, van der Meulen J H, Ravelli A C, Osmond C, Barker D J, Bleker O P
Department of Clinical Epidemiology, Academic Medical Centre, Amsterdam, The Netherlands.
Br J Haematol. 2000 Oct;111(1):112-7. doi: 10.1046/j.1365-2141.2000.02268.x.
To assess the effect of maternal malnutrition during different stages of gestation on plasma concentrations of fibrinogen and factor VII, we investigated 725 people, aged 50 years, born around the time of the Dutch famine 1944-5. After adjustment for sex, plasma fibrinogen concentrations differed by -0.01 g/l (95% confidence interval, -0.14-0.11) in those exposed in late gestation, by -0.03 g/l (-0.16-0.11) in those exposed in mid gestation, and by 0.13 g/l (-0.03-0.30) in those exposed in early gestation, compared with non-exposed people (those born before and those conceived after the famine pooled together). Plasma factor VII concentrations differed by 0.4% (-5.4% to 6.6%) in those exposed to famine in late gestation, by 1.5% (-4.6% to 8.1%) in those exposed in mid gestation. and by -11.8% (-18.4 to -4.8%) in those exposed in early gestation, compared with nonexposed people. Size at birth was not associated with plasma concentrations of fibrinogen or factor VII. Our finding that factor VII concentrations were significantly lower in people whose mothers had been exposed to famine in early pregnancy suggests that liver function may be affected by undernutrition in early gestation.
为评估孕期不同阶段母亲营养不良对血浆纤维蛋白原和凝血因子VII浓度的影响，我们对725名年龄为50岁、在1944 - 1945年荷兰饥荒时期前后出生的人进行了调查。在对性别进行调整后，与未暴露人群（饥荒前出生和饥荒后受孕的人群合并计算）相比，孕晚期暴露人群的血浆纤维蛋白原浓度差异为-0.01 g/l（95%置信区间，-0.14 - 0.11），孕中期暴露人群为-0.03 g/l（-0.16 - 0.11），孕早期暴露人群为0.13 g/l（-0.03 - 0.30）。孕晚期暴露于饥荒的人群血浆凝血因子VII浓度差异为0.4%（-5.4%至6.6%），孕中期暴露人群为1.5%（-4.6%至8.1%），孕早期暴露人群为-11.8%（-18.4至-4.8%）。出生时的体重与血浆纤维蛋白原或凝血因子VII浓度无关。我们的研究发现，母亲在孕早期暴露于饥荒的人群中凝血因子VII浓度显著较低，这表明孕早期营养不良可能会影响肝功能。
