在周期性波动剪切速率下的凝块生长。

Clot growth under periodically fluctuating shear rate.

作者信息

Hashimoto S

机构信息

Department of Electronic Engineering, Osaka Institute of Technology, Japan.

出版信息

Biorheology. 1994 Sep-Oct;31(5):521-32. doi: 10.3233/bir-1994-31502.

DOI:10.3233/bir-1994-31502

PMID:7833455

Abstract

To control the morphology of a clot formed on an artificial flow path in pulsatile blood flow, the hydrodynamic effect of periodically fluctuating shear rate on clot growth has been quantitatively investigated in vitro. Uniform shear rates were applied to a sample of beagle blood in the concave-convex cones system. These shear rates were sinusoidally fluctuated between a maximum and a minimum in one direction at frequencies between 0.1 and 0.6 Hz. Evaluation of clot growth was derived from a clot ratio, which was experimentally determined from the rate of increase of frictional torque between the two cones. The results show that clot growth is controlled so as not to occupy a large space when the minimum shear rate is higher than 100 s-1, or when the time of application of lower (< 100 s-1) shear rates is modified by the intermittent application of higher (> 500 s-1) shear rates as long as the frequency is less than 0.6 Hz.

摘要

为了控制在脉动血流中的人工流动路径上形成的凝块的形态，已在体外定量研究了周期性波动的剪切速率对凝块生长的流体动力学效应。在凹凸锥系统中，对小猎犬血液样本施加均匀的剪切速率。这些剪切速率在0.1至0.6 Hz的频率下，在一个方向上在最大值和最小值之间呈正弦波动。凝块生长的评估源自凝块比率，该比率通过实验从两个锥体之间摩擦扭矩的增加速率确定。结果表明，当最小剪切速率高于100 s-1时，或者当较低（<100 s-1）剪切速率的施加时间通过间歇性施加较高（>500 s-1）剪切速率进行调整且频率小于0.6 Hz时，凝块生长受到控制，不会占据很大空间。