口服氯胺酮成功治疗带状疱疹后神经痛。
Successful treatment of postherpetic neuralgia with oral ketamine.
作者信息
Hoffmann V, Coppejans H, Vercauteren M, Adriaensen H
机构信息
Department of Anesthesia, University Hospital of Antwerpen, Edegem, Belgium.
出版信息
Clin J Pain. 1994 Sep;10(3):240-2. doi: 10.1097/00002508-199409000-00011.
OBJECTIVE
To demonstrate the possibilities of the use of oral ketamine in the treatment of postherpetic neuralgia.
SETTING
A pain clinic in a university hospital.
PATIENT
A patient with postherpetic neuralgia of the ophthalmic nerve.
INTERVENTION
Subcutaneous and later oral ketamine after classical treatment had failed.
RESULTS
A complete recovery was accomplished without any sign of side effects.
CONCLUSIONS
Oral ketamine may provide an alternative in the treatment of postherpetic neuralgia. The possible mechanism of action by its N-methyl-D-aspartate (NMDA) blocking properties is discussed.
目的
证明口服氯胺酮用于治疗带状疱疹后神经痛的可能性。
背景
大学医院的疼痛诊所。
患者
一名患有眼神经带状疱疹后神经痛的患者。
干预措施
在传统治疗失败后，先采用皮下注射氯胺酮，随后口服氯胺酮。
结果
实现了完全康复，且无任何副作用迹象。
结论
口服氯胺酮可能为带状疱疹后神经痛的治疗提供一种替代方法。讨论了其通过N-甲基-D-天冬氨酸（NMDA）阻断特性可能的作用机制。
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