Ito M, Miyazaki A, Yamagishi T, Yagasaki H, Hashem A, Oshida Y
Department of Biomaterial, Institute for Dental Science, Matsumoto Dental College, Nagano, Japan.
Biomed Mater Eng. 1994;4(6):439-49.
Bone filling substances are needed to meet several requirements including nontoxicity, setting time, changes in pH values, and amount of dissolved elements as well as mechanical properties. In this study, the bone-generating composites were prepared by employing the in vivo absorbable beta-tricalcium phosphate as a parent matrix kneaded with CaO, MgO, and ZnO as bone mineral additives with different compositions. The setting time, pH values, compressive strength were investigated as a function of the amount of these bone mineral additives. It was found that the setting time was shortened by increasing CaO, MgO, and ZnO contents. Increasing ZnO contents resulted in the pH value lower, while the pH values increased by increasing CaO and MgO contents. Increasing ZnO contents caused the compressive strength stronger, on the other hand, the compressive strength was weakened by increasing MgO contents. Furthermore, calcium appears to be selectively released from the hardened composite sample.
骨填充材料需要满足多项要求，包括无毒性、凝固时间、pH值变化、溶解元素量以及机械性能等。在本研究中，通过将体内可吸收的β-磷酸三钙作为母体基质，与不同成分的氧化钙、氧化镁和氧化锌作为骨矿物质添加剂进行捏合，制备了骨生成复合材料。研究了这些骨矿物质添加剂用量对凝固时间、pH值和抗压强度的影响。结果发现，增加氧化钙、氧化镁和氧化锌的含量会缩短凝固时间。增加氧化锌含量会导致pH值降低，而增加氧化钙和氧化镁含量则会使pH值升高。增加氧化锌含量会使抗压强度增强，另一方面，增加氧化镁含量会削弱抗压强度。此外，钙似乎会从硬化的复合材料样品中选择性释放。
