In vitro properties of a chitosan-bonded hydroxyapatite bone-filling paste.

A possible bone substitute material for dental treatment was developed and tested. The material is composed of powdered hydroxyapatite (HA), ZnO and CaO, kneaded into a chitosan sol to make a quick-hardening paste. A composition was found which showed neutral pH, short setting time, and relatively high compressive strength. The use of such a paste for the treatment of periodontal defects or the augmentation of edentulous alveolar ridges may alleviate problems now associated with the implantation of particulate HA, such as early migration of particles and recontouring of the implant.