Tsouderos Y, Bauza-Canellas C, Decassin P, Denis M, Cusset B, Audrain S
Institut de Recherches Internationales Servier, Courbevoie.
Rev Rhum Ed Fr. 1994 Jun;61(6):439-46.
The need for determining country-specific reference bone mineral density values has been emphasized. The effects of age and time since menopause on femoral neck bone mineral density in healthy women are still insufficiently documented. The goal of this study was to determine age-specific femoral neck bone mineral density values and postmenopausal bone loss rates in French women. Dual-energy X-ray absorptiometry was used to measure lumbar spine, femoral neck, and Ward's triangle bone mineral densities in 827 women aged 36 to 86 years. Inclusion criteria included a negative history for established or suspected osteoporosis. A cross-sectional, retrospective design was used. Lumbar spine bone mineral densities were similar to reference values reported previously in healthy subjects from other countries. Consequently, we considered that the femoral neck values that we obtained were those of a healthy population. Results were as follows: 1) The annual rate of bone loss at the femur increased within one or two years after menopause (to 1.5% and 2% at the femoral neck and Ward's triangle, respectively), remained high for 12-13 years, then declined (0.8% and 1.2%, respectively). 2) Femoral bone loss was slow before the age of 55 years (0.2% and 0.5% per year) and continued at a faster rate thereafter (1.3% and 1.7% per year). Our study provides normal reference femoral bone mineral density values for French women. Our data confirm that age and time since the menopause have a substantial influence on bone mineral density, not only at the lumbar spine, but also at the femoral neck.
确定特定国家的参考骨矿物质密度值的必要性已得到强调。年龄和绝经后时间对健康女性股骨颈骨矿物质密度的影响仍缺乏充分记录。本研究的目的是确定法国女性特定年龄的股骨颈骨矿物质密度值和绝经后骨质流失率。采用双能X线吸收法测量了827名年龄在36至86岁女性的腰椎、股骨颈和沃德三角区的骨矿物质密度。纳入标准包括既往无确诊或疑似骨质疏松症病史。采用横断面回顾性设计。腰椎骨矿物质密度与其他国家先前报道的健康受试者参考值相似。因此，我们认为我们获得的股骨颈值是健康人群的值。结果如下：1）绝经后一两年内股骨骨质流失率增加（股骨颈和沃德三角区分别增至1.5%和2%），在12至13年内保持较高水平，然后下降（分别为0.8%和1.2%）。2）55岁之前股骨骨质流失缓慢（每年0.2%和0.5%），此后继续以较快速度流失（每年1.3%和1.7%）。我们的研究提供了法国女性正常的参考股骨骨矿物质密度值。我们的数据证实，年龄和绝经后时间不仅对腰椎骨矿物质密度，而且对股骨颈骨矿物质密度都有重大影响。
