Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T
Department of Neurology, Chiba University, Japan.
Brain Res. 1994 Sep 26;658(1-2):163-7. doi: 10.1016/s0006-8993(09)90022-1.
Human liver carboxylesterase (CE) is an enzyme capable of metabolizing drugs, and may also function as a regulator of lipid metabolism. We examined one isoform of CE by immunohistochemistry in the brains of neurologically normal, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and cerebral infarction cases. In all but the infarcted brains, the anti-CE antibody stained only capillary endothelial cells in the brain and spinal cord tissues. In infarct brain areas, intense immunoreactivity of the macrophages was seen. In contrast, the macrophages in the ALS lateral columns and the reactive microglia located in the center of classical senile plaques in AD, as well as other reactive microglial cells in the grey matter, showed no immunoreactivity. In the central nervous system, CE may function as a protective factor against foreign chemicals in capillary endothelial cells, and the antibody to CE may serve as a marker for invading macrophages from the systemic circulation.
人肝脏羧酸酯酶（CE）是一种能够代谢药物的酶，也可能作为脂质代谢的调节剂发挥作用。我们通过免疫组织化学方法，在神经功能正常者、阿尔茨海默病（AD）患者、肌萎缩侧索硬化症（ALS）患者及脑梗死患者的大脑中检测了CE的一种同工型。除梗死脑外，抗CE抗体仅在脑和脊髓组织中的毛细血管内皮细胞上染色。在梗死脑区，可见巨噬细胞有强烈的免疫反应性。相比之下，ALS侧柱中的巨噬细胞、AD经典老年斑中心的反应性小胶质细胞以及灰质中的其他反应性小胶质细胞均无免疫反应性。在中枢神经系统中，CE可能作为毛细血管内皮细胞抵御外来化学物质的保护因子发挥作用，而抗CE抗体可能作为来自体循环的入侵巨噬细胞的标志物。
