Trope G E, Cheng Y L, Sheardown H, Liu G S, Menon I A, Heathcote J G, Rootman D S, Chiu W J, Gould L
Department of Ophthalmology, University of Toronto, ON.
Can J Ophthalmol. 1994 Dec;29(6):263-7.
We investigated the potential value of 50:50 poly (DL glycolic acid-lactic acid) (PGLA) copolymer as a degradable depot delivery system for 5-fluorouracil (5-FU) after filtration surgery. Analysis of retrieved discs after implantation in 22 eyes of 22 pigmented rabbits showed a dual drug release profile and polymer mass loss characteristics. In a second group of pigmented rabbits implantation of PGLA discs impregnated with 5-FU (22 eyes) significantly lengthened the survival time of filtration fistulae compared with discs without 5-FU (18 eyes) or no disc (10 eyes) (p < 0.0001). Use of PGLA copolymer impregnated with 5-FU could prove valuable for patients undergoing glaucoma filtering surgery.
我们研究了50:50聚（DL-乙醇酸-乳酸）（PGLA）共聚物作为5-氟尿嘧啶（5-FU）在滤过性手术后可降解长效给药系统的潜在价值。对22只有色家兔22只眼植入后取出的圆盘进行分析，显示出双相药物释放曲线和聚合物质量损失特征。在第二组有色家兔中，与未含5-FU的圆盘（18只眼）或无圆盘（10只眼）相比，植入含5-FU的PGLA圆盘（22只眼）显著延长了滤过瘘管的存活时间（p<0.0001）。含5-FU的PGLA共聚物的应用可能对接受青光眼滤过手术的患者有价值。
