Gould L, Trope G, Cheng Y L, Heathcote J G, Sheardown H, Rootman D, Liu G S, Menon I A
Department of Ophthalmology, University of Toronto, Ont.
Can J Ophthalmol. 1994 Aug;29(4):168-71.
Fifty:fifty poly (DL glycolic acid-lactic acid) copolymer (PGLA) is a potentially useful depot drug delivery system for 5-fluorouracil (5-FU). The purpose of this study was to evaluate the fibroinflammatory reaction induced by this polymer. Polymer discs without 5-FU were inserted subconjunctivally in one eye of each of two guinea pigs and four pigmented rabbits (control group), and discs containing 20% 5-FU were inserted subconjunctivally in both eyes of nine pigmented rabbits (study group). The tissue reaction to the copolymer did not differ between rabbits and guinea pigs, with a mild mixed inflammatory reaction 1 week after implantation. At 2 weeks a thin fibrous capsule surrounded the discs, with no change in the amount of inflammation. At 4 weeks the disc had disintegrated, but residual polymer was seen within multinucleated giant cells in the episcleral tissue. Granulation tissue and inflammatory responses were mild. Less inflammation and fibrosis occurred in the study eyes, although the pattern of response was similar in the two groups. The inflammatory response to PGLA was markedly less than that to implanted collagen shields, and our findings suggest that PGLA implant is a promising ocular drug delivery system for 5-FU after filtration surgery.
50:50聚（DL-乙醇酸-乳酸）共聚物（PGLA）是一种用于5-氟尿嘧啶（5-FU）的潜在有用的长效药物递送系统。本研究的目的是评估该聚合物引起的纤维炎症反应。在两只豚鼠和四只有色兔的每只动物的一只眼睛结膜下植入不含5-FU的聚合物圆盘（对照组），在九只有色兔的双眼结膜下植入含20% 5-FU的圆盘（研究组）。兔和豚鼠对该共聚物的组织反应无差异，植入后1周出现轻度混合性炎症反应。2周时，圆盘周围形成一层薄的纤维囊，炎症程度无变化。4周时圆盘已分解，但在巩膜上组织的多核巨细胞内可见残留的聚合物。肉芽组织和炎症反应较轻。研究组眼中的炎症和纤维化较少，尽管两组的反应模式相似。对PGLA的炎症反应明显小于对植入胶原盾的反应，我们的研究结果表明，PGLA植入物是滤过性手术后用于5-FU的一种有前景的眼部药物递送系统。
