Ip C, Vadhanavikit S, Ganther H
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263.
Carcinogenesis. 1995 Jan;16(1):35-8.
The objective of this study was to examine the anticarcinogenic activity of a series of aliphatic selenocyanates with increasing length of the carbon side chain, CH3-(CH2)n-SeCN, in which n = 0, 2, 4 or 6. Their ability to prevent mammary cancer was evaluated during the initiation phase using the rat 7,12-dimethyl-benz[a]anthracene (DMBA) model. Each compound was added to the diet at a final concentration of 2 p.p.m. Se and was given from 2 weeks before to 1 week after DMBA administration. Analysis of the tumor data suggested the following order of chemopreventive potency for this series of aliphatic selenocyanates: heptyl approximately pentyl > propyl > methyl. Thus it appears that the length of the carbon side chain is a determinant in modulating the efficacy of these selenium homologs. In vivo results of total DMBA binding and adduct formation in the mammary cells showed a similar trend of progressive reductions following treatment by selenocyanates with increasing length of the alkyl side chain. These studies strongly indicate that aliphatic selenocyanates are effective blocking agents in the DMBA model and are capable of modulating events in the initiation phase of mammary carcinogenesis.
本研究的目的是检测一系列碳侧链长度不断增加的脂肪族硒氰酸盐（CH3-(CH2)n-SeCN，其中n = 0、2、4或6）的抗癌活性。在起始阶段，使用大鼠7,12-二甲基苯并[a]蒽（DMBA）模型评估它们预防乳腺癌的能力。将每种化合物以2 ppm硒的终浓度添加到饮食中，在给予DMBA前2周开始给药，持续至给予DMBA后1周。对肿瘤数据的分析表明，该系列脂肪族硒氰酸盐的化学预防效力顺序如下：庚基≈戊基＞丙基＞甲基。因此，碳侧链的长度似乎是调节这些硒同系物功效的一个决定因素。乳腺细胞中总DMBA结合和加合物形成的体内结果显示，在用烷基侧链长度增加的硒氰酸盐处理后，呈现出类似的逐渐降低趋势。这些研究有力地表明，脂肪族硒氰酸盐在DMBA模型中是有效的阻断剂，并且能够调节乳腺癌发生起始阶段的相关事件。
