Lilienthal H, Kohler K, Turfeld M, Winneke G
Department of Psychophysiology, Medical Institute of Environmental Hygiene, Düsseldorf, Germany.
Exp Eye Res. 1994 Aug;59(2):203-9. doi: 10.1006/exer.1994.1098.
The electroretinogram (ERG) of rhesus monkeys was re-examined more than 2 years after termination of lead exposure when mean blood lead levels had declined to values below 10 micrograms dl-1. Amplitude of the b-wave was increased by lead exposure at scotopic conditions, while there were no changes in photopic signals. The lead-induced effects were similar to alterations detected during the treatment phase and, thus, are not dependent on current exposure. Taking into account, that dopamine antagonists cause similar changes in the ERG, it is suggested that the observed effects may be mediated by a permanent change of dopaminergic processes since immunoreactivity also revealed adverse effects on the dopaminergic system in the retinae of these monkeys.
在恒河猴停止铅暴露两年多后，对其视网膜电图（ERG）进行了重新检查，此时平均血铅水平已降至10微克/分升以下。在暗视条件下，铅暴露会增加b波的振幅，而明视信号则没有变化。铅诱导的效应与治疗阶段检测到的变化相似，因此不依赖于当前的暴露情况。考虑到多巴胺拮抗剂会在ERG中引起类似的变化，有人提出，观察到的效应可能是由多巴胺能过程的永久性变化介导的，因为免疫反应性也显示出对这些猴子视网膜多巴胺能系统的不利影响。
