进一步的证据表明，大鼠对5-羟色胺的心动过速反应不是通过典型的5-HT2受体介导的。

Further evidence that the tachycardiac response to 5-hydroxytryptamine in rats is not mediated via typical 5-HT2 receptors.

Krstić M K, Katusić Z S

Department of Pharmacology, Faculty of Medicine, Belgrade, Serbia.

Gen Pharmacol. 1994 Sep;25(5):917-21. doi: 10.1016/0306-3623(94)90096-5.

Abstract

In pithed rats, the receptor type of cardiac tissue mediating the tachycardiac response to 5-hydroxytryptamine (5-HT) was analysed. 2. Ketanserin, mesulergine and methiothepin, administered in doses which antagonized the pressor response to 5-HT, slightly reduced, considerably reduced and antagonized, respectively, its tachycardiac response. 3. 8-OH DPAT and RU 24969 produced no significant tachycardia, while DOI neither mimicked nor blocked the 5-HT-induced tachycardia. 4. The tachycardia was not affected by MDL 72222, metoclopramide and cocaine. 5. The hypothesis is proposed that in rats the tachycardiac response to 5-HT is mediated via 5-HT receptors belonging to an yet unclassified subtype of 5-HT1 or 5-HT2 receptors.

摘要

在脊髓被横断的大鼠中，分析了介导对5-羟色胺（5-HT）心动过速反应的心脏组织受体类型。2. 给予能拮抗对5-HT升压反应剂量的酮色林、甲硫哒嗪和美替拉酮，分别使其心动过速反应略有降低、显著降低和受到拮抗。3. 8-OH DPAT和RU 24969未产生明显的心动过速，而DOI既不模拟也不阻断5-HT诱导的心动过速。4. 心动过速不受MDL 72222、甲氧氯普胺和可卡因的影响。5. 提出的假设是，在大鼠中，对5-HT的心动过速反应是通过属于5-HT1或5-HT2受体未分类亚型的5-HT受体介导的。