Azzarito C, Boiardi L, Zini M, Agosti A, Biacchessi M, Biagi R, Portioli I
IIa Divisione di Medicina Interna, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Horm Metab Res. 1994 Sep;26(9):432-5. doi: 10.1055/s-2007-1001724.
Since recombinant growth hormone (GH) has been available, its use has been extended to treating not only children with growth hormone deficiency, but also short-statured children without GH deficiency. It is interesting, therefore, to determine whether GH therapy given in conventional doses causes metabolic side effects in these patients. In the present study we have examined the effect of recombinant human GH on eleven short normal children. Patients received 12 U/m2/week for 1 year. Before beginning treatment, the children had a mean annual growth velocity of 5.1 +/- 0.9 cm/yr; during the year of treatment, the therapy was effective and improved the mean growth velocity to 7.1 +/- 1.7 cm/yr, p < 0.05. We evaluated the subacute short-term effects during the first 15 days of treatment and the long-term effects for one year of GH treatment on lipid and lipoprotein levels. We found a significant increase in total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) at the 6th month. Triglycerides (TG) increased significantly at the 3rd and 6th month. Both TC and TG returned to baseline at the 12th month. In no case however did the levels of TC, LDL-C and TG go above normal nor were there any changes in the following tests: high density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A-I, Apo B, Apo C-II, Apo C-III and Apo E. In conclusion, conventional doses of GH given to short normal children are effective in ameliorating growth velocity and do not cause serious metabolic side effects.
自从重组生长激素（GH）问世以来，其应用范围已扩大到不仅治疗生长激素缺乏的儿童，还包括非生长激素缺乏的身材矮小儿童。因此，确定常规剂量的生长激素治疗是否会在这些患者中引起代谢副作用是很有意思的。在本研究中，我们检查了重组人生长激素对11名身材正常的矮小儿童的影响。患者接受12 U/m²/周的治疗，持续1年。在开始治疗前，这些儿童的平均年生长速度为5.1±0.9厘米/年；在治疗的这一年中，治疗有效，平均生长速度提高到7.1±1.7厘米/年，p<0.05。我们评估了治疗前15天的亚急性短期影响以及生长激素治疗一年对血脂和脂蛋白水平的长期影响。我们发现，在第6个月时总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）显著升高。甘油三酯（TG）在第3个月和第6个月时显著升高。在第12个月时，TC和TG均恢复到基线水平。然而，在任何情况下，TC、LDL-C和TG水平均未超过正常范围，以下检查也没有任何变化：高密度脂蛋白胆固醇（HDL-C）、载脂蛋白（Apo）A-I、Apo B、Apo C-II、Apo C-III和Apo E。总之，给予身材正常的矮小儿童常规剂量的生长激素可有效改善生长速度，且不会引起严重的代谢副作用。
