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通过自身反应性混合单倍型Aβz/Aαd MHC II类分子特异性CD4 + T细胞克隆在体内诱导IgG抗DNA抗体

In vivo induction of IgG anti-DNA antibody by autoreactive mixed haplotype A beta z/A alpha d MHC class II molecule-specific CD4+ T-cell clones.

作者信息

Tokushima M, Koarada S, Hirose S, Gotoh Y, Nishimura H, Shirai T, Miyake K, Kimoto M

机构信息

Department of Immunology, Saga Medical School, Japan.

出版信息

Immunology. 1994 Oct;83(2):221-6.

PMID:7835938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1414947/
Abstract

We characterized autoreactive T-cell clones derived from (NZB x NZW)F1 (B/WF1) mice. These autoreactive T-cell clones are shown to be CD4+ by immunofluorescence staining and to belong to Th2 type by cytokine release assay. Specificity analysis revealed the existence of mixed haplotype A beta z/A alpha d major histocompatibility complex (MHC) class II molecule-specific T-cell clones as well as A beta z/A alpha z- or A beta d/A alpha d-specific T-cell clones. Some but not all of the mixed haplotype A beta z/A alpha d-specific autoreactive T-cell clones showed strong activity to induce IgG anti-DNA antibody production upon transfer to young (4-month-old) B/WF1 mice, indicating that T cells with these specificities might be involved in B/WF1 autoimmunity.

摘要

我们对源自（新西兰黑鼠×新西兰白鼠）F1（B/WF1）小鼠的自身反应性T细胞克隆进行了表征。通过免疫荧光染色显示，这些自身反应性T细胞克隆为CD4+，通过细胞因子释放试验表明它们属于Th2型。特异性分析揭示了存在混合单倍型Aβz/Aαd主要组织相容性复合体（MHC）II类分子特异性T细胞克隆以及Aβz/Aαz或Aβd/Aαd特异性T细胞克隆。部分（而非全部）混合单倍型Aβz/Aαd特异性自身反应性T细胞克隆在转移至年轻（4个月大）的B/WF1小鼠后，表现出强烈的诱导IgG抗DNA抗体产生的活性，这表明具有这些特异性的T细胞可能参与了B/WF1小鼠的自身免疫反应。

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本文引用的文献

1
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J Immunol. 1993 Jun 1;150(11):4777-87.
2
Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain.通过编码I-Eα链的转基因预防自身免疫性BXSB小鼠的系统性红斑狼疮。
J Exp Med. 1993 Oct 1;178(4):1189-97. doi: 10.1084/jem.178.4.1189.
3
A peptide derived from an autoantibody can stimulate T cells in the (NZB x NZW)F1 mouse model of systemic lupus erythematosus.一种源自自身抗体的肽可在系统性红斑狼疮的（新西兰黑鼠×新西兰白鼠）F1小鼠模型中刺激T细胞。
Arthritis Rheum. 1993 Mar;36(3):355-64. doi: 10.1002/art.1780360311.
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Studies of congenitally immunologically mutant New Zealand mice. IV. Development of autoimmunity in congenitally athymic (nude) New Zealand Black x White F1 hybrid mice.先天性免疫突变新西兰小鼠的研究。IV. 先天性无胸腺（裸）新西兰黑×白F1杂交小鼠自身免疫的发展。
J Immunol. 1980 Sep;125(3):1189-95.
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J Immunol. 1981 Nov;127(5):1936-40.
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