Doran T J, Davies J K, Radford A J, Hodgson A L
CSIRO Division of Animal Health, Melbourne, Victoria, Australia.
Immunol Cell Biol. 1994 Oct;72(5):427-34. doi: 10.1038/icb.1994.63.
Repeated DNA sequences have been identified in a range of mycobacterial species and have been implicated in the increased virulence of some of these species, namely, Mycobacterium paratuberculosis and M. avium subsp. silvaticum. Here we present a case to suggest that the insertion sequences IS900 and IS902 encode a protein from a putative gene positioned on the complementary strand to their transposase genes. Based on amino acid homology analyses, this open reading frame (ORF2) could encode a transport protein. The ORF2 protein thus IS900 and IS902, may have a role in the increased pathogenicity of M. paratuberculosis and M. avium subsp. silvaticum from an M. avium background.
在一系列分枝杆菌物种中已鉴定出重复DNA序列，并且这些序列与其中一些物种（即副结核分枝杆菌和鸟分枝杆菌亚种）毒力的增加有关。在此，我们展示一个案例，表明插入序列IS900和IS902从位于与其转座酶基因互补链上的一个假定基因编码一种蛋白质。基于氨基酸同源性分析，这个开放阅读框（ORF2）可能编码一种转运蛋白。因此，IS900和IS902的ORF2蛋白可能在来自鸟分枝杆菌背景的副结核分枝杆菌和鸟分枝杆菌亚种致病性增加中发挥作用。
