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Nucleic Acids Res. 1989 Nov 25;17(22):9063-73. doi: 10.1093/nar/17.22.9063.
2
IS902, an insertion element of the chronic-enteritis-causing Mycobacterium avium subsp. silvaticum.IS902，一种导致慢性肠炎的鸟分枝杆菌亚种——森林分枝杆菌的插入元件。
J Gen Microbiol. 1992 Jan;138(1):139-45. doi: 10.1099/00221287-138-1-139.
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Discovery of an insertion sequence, IS116, from Streptomyces clavuligerus and its relatedness to other transposable elements from actinomycetes.从棒状链霉菌中发现插入序列IS116及其与放线菌其他转座元件的相关性。
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Specific detection of Mycobacterium paratuberculosis by DNA hybridisation with a fragment of the insertion element IS900.通过与插入元件IS900的一个片段进行DNA杂交来特异性检测副结核分枝杆菌。
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Molecular biology of Crohn's disease mycobacteria.克罗恩病分枝杆菌的分子生物学
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Insertion sequence IS900 revisited.插入序列IS900再探讨。
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Putative functional domain within ORF2 on the Mycobacterium insertion sequences IS900 and IS902.分枝杆菌插入序列IS900和IS902上ORF2内的推定功能域。
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本文引用的文献

1
Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing.DNA测序鸟枪法产生的凝胶读数数据的计算机处理自动化。
Nucleic Acids Res. 1982 Aug 11;10(15):4731-51. doi: 10.1093/nar/10.15.4731.
2
Codon preference and its use in identifying protein coding regions in long DNA sequences.密码子偏好性及其在长DNA序列中识别蛋白质编码区的应用。
Nucleic Acids Res. 1982 Jan 11;10(1):141-56. doi: 10.1093/nar/10.1.141.
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A comprehensive set of sequence analysis programs for the VAX.一套适用于VAX的综合序列分析程序。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95. doi: 10.1093/nar/12.1part1.387.
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Measurements of the effects that coding for a protein has on a DNA sequence and their use for finding genes.蛋白质编码对DNA序列的影响的测量及其在寻找基因中的应用。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):551-67. doi: 10.1093/nar/12.1part2.551.
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Graphic methods to determine the function of nucleic acid sequences.用于确定核酸序列功能的图解方法。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):521-38. doi: 10.1093/nar/12.1part2.521.
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Computer methods to locate signals in nucleic acid sequences.在核酸序列中定位信号的计算机方法。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 2):505-19. doi: 10.1093/nar/12.1part2.505.
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New M13 vectors for cloning.用于克隆的新型M13载体。
Methods Enzymol. 1983;101:20-78. doi: 10.1016/0076-6879(83)01005-8.
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High-frequency spontaneous mutation in the bacterio-opsin gene in Halobacterium halobium is mediated by transposable elements.嗜盐菌视紫红质基因中的高频自发突变由转座元件介导。
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2201-5. doi: 10.1073/pnas.80.8.2201.
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Structural requirement for IS50-mediated gene transposition.IS50介导的基因转座的结构要求。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):792-6. doi: 10.1073/pnas.80.3.792.
10
Nucleotide sequence of the insertion sequence found in the T-DNA region of mutant Ti plasmid pTiA66 and distribution of its homologues in octopine Ti plasmid.在突变型Ti质粒pTiA66的T-DNA区域发现的插入序列的核苷酸序列及其同源物在章鱼碱型Ti质粒中的分布
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7495-9. doi: 10.1073/pnas.81.23.7495.

IS900的序列与特征，IS900是在一株人副结核分枝杆菌克罗恩病分离株中鉴定出的插入元件。

Sequence and characteristics of IS900, an insertion element identified in a human Crohn's disease isolate of Mycobacterium paratuberculosis.

作者信息

Green E P, Tizard M L, Moss M T, Thompson J, Winterbourne D J, McFadden J J, Hermon-Taylor J

机构信息

Department of Surgery, St Georges Hospital Medical School, London, UK.

出版信息

Nucleic Acids Res. 1989 Nov 25;17(22):9063-73. doi: 10.1093/nar/17.22.9063.

DOI:10.1093/nar/17.22.9063
PMID:2555783
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335114/
Abstract

The complete sequence of an insertion element IS900 in Mycobacterium paratuberculosis is reported. This is the first characterised example of a mycobacterial insertion element. IS900 consists of 1451bp of which 66% is G + C. It lacks terminal inverted and direct repeats, characteristic of Escherichia coli insertion elements but shows a degree of target sequence specificity. A single open reading frame (ORF 1197) coding for 399 amino acids is predicted. This amino acid sequence, and to a lesser extent the nucleotide sequence, show significant homologies to IS110, an insertion element of Streptomyces coelicolor A3(2). It is proposed that IS900, IS110, and similar insertion elements recently identified in disease isolates of Mycobacterium avium are members of a phylogenetically related family. IS900 will provide highly specific markers for the precise identification of Mycobacterium paratuberculosis, useful in defining its relationship to animal and human diseases.

摘要

报道了副结核分枝杆菌中插入元件IS900的完整序列。这是分枝杆菌插入元件的首个经鉴定的实例。IS900由1451个碱基对组成，其中66%为G + C。它缺乏大肠杆菌插入元件所特有的末端反向重复序列和正向重复序列，但表现出一定程度的靶序列特异性。预测有一个编码399个氨基酸的单一开放阅读框（ORF 1197）。该氨基酸序列以及在较小程度上的核苷酸序列与天蓝色链霉菌A3(2)的插入元件IS110具有显著同源性。有人提出，IS900、IS110以及最近在鸟分枝杆菌疾病分离株中鉴定出的类似插入元件是一个系统发育相关家族的成员。IS900将为副结核分枝杆菌的精确鉴定提供高度特异性的标记，有助于确定其与动物和人类疾病的关系。