Personality and drug preferences in normal volunteers.

This study examined the relationship between drug preferences as measured in a laboratory-based choice procedure and measures of personality and attitudes toward drugs. Healthy volunteers participated in laboratory-based double-blind studies measuring preference for ethanol or diazepam vs placebo. Frequency of drug choice was examined in relation to subjects' scores on personality questionnaires. Drug choice was not related to any of the personality measures examined. Personality scores were, however, related to both gender and habitual drug use. These data suggest that personality does not strongly influence responses to single doses of drugs as assessed under controlled conditions. Personality may, nevertheless, affect drug use in natural settings via other mechanisms (e.g., interacting with psychosocial variables).