在北美家族中，DNA标记D11S384与共济失调毛细血管扩张症基因座无重组现象。
DNA marker D11S384 shows zero recombination with the ataxia-telangiectasia locus in North American families.
作者信息
Lench N J, Athma P, Ottaiano A, Sribney W M, Highsmith E, Swift M
机构信息
Division of Human Molecular Genetics, New York Medical College, Valhalla.
出版信息
Int J Radiat Biol. 1994 Dec;66(6 Suppl):S67-9.
PMID:7836855
Abstract
At the genetic locus D11S384, one probe detects a Taql RFLP and another detects a RFMP. In 52 pedigrees of North American A-T patients, parental haplotypes based on these two bi-allelic systems have a heterozygosity of 0.69 and a PIC of 0.64. No recombinant events between D11S384 and the A-T locus were detected in the 43 pedigrees in which this marker locus was informative.
摘要
在基因座D11S384处，一个探针检测到TaqI限制性片段长度多态性（RFLP），另一个探针检测到限制性片段微卫星多态性（RFMP）。在52个北美共济失调毛细血管扩张症（A-T）患者家系中，基于这两个双等位基因系统的亲代单倍型杂合度为0.69，多态信息含量（PIC）为0.64。在该标记基因座具有信息性的43个家系中，未检测到D11S384与A-T基因座之间的重组事件。
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